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Early oral administration of Lcarnitine significantly delayed symptom onset prolonged motor function as assessed by rotorod and extended survival in SOD1 transgenic mice In a second experiment 20 transgenic mice were injected with Lcarnitine every two days after symptom onset Survival of these mice was compared to that of 20 transgenic mice not receiving.

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Motor function is selfreported as important to a patient’s quality of life fortunately it is a quantifiable phenotype closely aligned between model organisms and patients that is measurable using traditional clinical assessments and biometric devices providing avenues for the preclinicaltoclinical translation of drugeffects 144–146 Motor deficits in the Line 61.

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